PROBLEM TO BE SOLVED: To provide a composition for treating cancer, such as cancer associated with enzyme phosphatase - tension homolog (PTEN) deficiency, small cell lung cancer, meningioma, head and neck cancer, glioblastoma multiforme, anaplastic astrocytoma, and colorectal cancer.SOLUTION: According to the present invention, there is provided a composition comprising a therapeutically effective amount of a compound of formula (I), or a single isomer, stereoisomer, enantiomer, or a mixture thereof. (in the formula, the groups Y and Z are each independently a substituted aryl group or heteroaryl group H, alkenyl, alkoxy, alkyl, etc.; Rto Rare each independently H, halogen, alkenyl, alkoxy, etc.; A and B are each independently H, halogen, alkyl, OH, etc.; Rand Rare each independently H, alkyl, cycloalkyl etc.)SELECTED DRAWING: Figure 1【課題】酵素ホスファターゼ-テンションホモログ(PTEN)の欠損に関連した癌、小細胞肺癌、髄膜腫、頭頸部癌、多形成膠芽腫、退形成性星細胞腫、及び結腸直腸癌などの癌を治療するための組成物の提供。【解決手段】式(I)で表される化合物、又は単一の異性体、立体異性体、エナンチオマー或いはそれの混合物の治療上有効量を含む、組成物。(基Y及びZは夫々独立に置換されたアリール基又は、ヘテロアリール基H、アルケニル、アルコキシ、アルキル等;R1~R3は夫々独立にH、ハロゲン、アルケニル、アルコキシ等;A及びBは夫々独立にH、ハロゲン、アルキル、OH等;R4及びR5は夫々独立にH、アルキル、シクロアルキル等)【選択図】図1