OLSEN, JOHAN GOTTHARDT,KADZIOLA, ANDERS,DAHL, SOREN WEIS,LAURITZEN, CONNIE,LARSEN, SINE,PEDERSEN, JOHN,TURK, DUSAN,PODOBNIK, MARJETKA,STERN, IGOR
申请号：
CA2422057
公开号：
CA2422057C
申请日:
2001.09.06
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention relates to structural studies of dipeptidyl peptidase I(DPPI) proteins, modified dipeptidyl peptidase I (DPPI) proteins and DPPI co-complexes. Included in the present invention is a crystal of a dipeptidylpeptidase I (DPPI) and corresponding structural information obtained by X-raycrystallography from rat and human DPPI. In addition, this invention relatesto methods for using structure co-ordinates of DDPI, mutants hereof andco-complexes, to design compounds that bind to the active site or accessorybinding sites of DPPI and to design improved inhibitors of DPPI or homologuesof the enzyme.
