A R KULKARNI,A R KULKARNI,B S PATIL,B S PATIL,B H YENNI,B H YENNI
申请号：
IN959/CHE/2014
公开号：
IN2014CH00959A
申请日:
2014.02.26
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
The invention is about to produce orodispersible tablets containing various naturally occurring mouth fresheners extracted from fennel {Foeniculum vulgare Mill, of family umbeliferae), ginger {Zingiber officinale Roscoe of family Zingiberaceae) and cardamom {Elettaria cardamomum Motanvar of family Zingiberaceae). The developed formulations are elegant in the form of solid unit dosage forms which are easy to handle and can be packed in to attractive blister or strip packs. Traditionally used crude drugs such as fennel, cardamom, ginger, clove etc., are made available in the form of orodispersible tablets so as to increase their stability. The novel formulations have potential advantages over conventional dosage forms, with their improved patient compliance, convenience, bioavailability and rapid onset of action. Orodispersible tablet formulations have sufficient mechanical strength, quick disintegration/dissolution in the mouth without water. Volatile oils from respective drugs were isolated by Hydrodistillation method using Clevenger"s apparatus using water as a solvent. The yield of volatile oil obtained from fennel was 0.43%w/v, from cardamom was 8.50%w/v and from ginger was 0.64%w/v. Extracted oils were dispersed with mannitol using alcohol and used for direct punching using superdisintegrants, viz., sodium starch glycolate. The prepared batches of tablets were evaluated for thickness, weight variation, hardness, friability and in-vitro disintegration time. Based on actual disintegration followed by dissolution of tablet in a glass was measured in-vitro disintegration time.
