The presently disclosed invention and particular invention embodiments relate to formulations, methods, procedures, and combinations thereof for treating numerous types of trauma-induced and other neurological disorders and injuries, such as but not exclusive to brain injury, central nervous system ischemia, spinal cord injury, enteric nervous system injury and peripheral nerve injury. The formulations of the present invention comprising two, three or four biologically active compounds selected from: A. at least one biologically active compound selected from anticonvulsants and antiepileptics； B. at least one biologically active compound selected from neurosteroids and neuroactive steroids； C. at least one biologically active compound selected from NK-1 receptor antagonists； and D. at least one biologically active compound selected from lithium containing and lithium-related compounds.
