INHIBITEURS DES VOIES BIOLOGIQUES MEK/P13K, JAK/MEK, JAK/P13K/MTOR ET MEK/P13K/MTOR ET PROCEDES D'AMELIORATION DE L'ABSORPTION LYMPHATIQUE, DE LA BIODISPONIBILITE ET DE LA SOLUBILITE DE COMPOSES THERAPEUTIQUES
Inhibitors of mTOR, MEK, JAK and PI3K and compositions containing the same aredisclosed. Methods of usingthe inhibitors in the treatment of a variety of diseases and conditionswherein inhibition of one or more of mTOR, MEK, JAK andPI3K provides a benefit also are disclosed. Methods of using chemicalattachment moieties and linkers for the purposes of modifyingcompound solubility and/or lymphatic absorption are also disclosed.
