Thomas Kodadek;Rolf Brekken;D. Gomika Udugamasooriya
发明人:
Thomas Kodadek,D. Gomika Udugamasooriya,Rolf Brekken
申请号：
US12950425
公开号：
US09233162B2
申请日:
2010.11.19
申请国别(地区):
US
年份:
2016
代理人:
摘要：
A cell-based screen is reported can be used to identify specific receptor-binding compounds in a combinatorial library of peptoids (N-alkylglycine oligomers) displayed on beads. This strategy was applied to the isolation of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)-binding peptoids, which were optimized to create lead compounds with high affinity for VEGFR2. One of these peptoids was shown to be an antagonist of VEGF-VEGFR2 interaction and receptor function.
