VINCENT P. SANDANAYAKA,SHARON SHACHAM,DILARA MCCAULEY,SHARON SHECHTER
申请号:
PT12743846
公开号:
PT2736887T
申请日:
2012.07.26
申请国别(地区):
PT
年份:
2018
代理人:
摘要:
The invention generally relates to nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to a compound represented by structural formula I: or a pharmaceutically acceptable salt thereof, wherein the values and alternative values for the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.