Nucleic acid constructs encoding reprogramming factors linked by self-cleaving peptides

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专利权人:

Bryce Woodbury Carey;Rudolf Jaenisch

发明人:

Rudolf Jaenisch,Bryce Woodbury Carey

申请号：

US12997815

公开号：

US09497943B2

申请日:

2009.06.15

申请国别(地区):

US

年份:

2016

代理人:

摘要：

The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to chimeric animals comprising reprogrammed somatic cells of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.

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