JUNG, Hee Jung,정희정,CHAE, Chong Hak,채종학,HA, Jae Du,하재두,HWANG, Jong Yeon,황종연,KIM, Hyung Rae,김형래,KIM, Pilho,김필호,PARK, Chi Hoon,박지훈,AHN, Sun Joo,안선주,YUN, Chang Soo,윤창수,LEE, Kwangho,이광호,LEE, Chong Ock,이정옥
申请号：
KRKR2015/000737
公开号：
WO2015/130014A1
申请日:
2015.01.23
申请国别(地区):
WO
年份:
2015
代理人:
摘要：
The present invention relates to a pyrimidine-2,4-diamine derivative or pharmaceutically acceptable salts thereof, and a pharmaceutical composition for preventing or treating cancer, which contains a pyrimidine-2,4-diamine derivative as an active ingredient. A compound according to the present invention is very effective in suppressing anaplastic lymphoma kinase (ALK) activity, and as a result, can improve the effectiveness of treatment on cancer cells having anaplastic lymphoma kinase (ALK) fusion proteins, such as EML4-ALK and NPM-ALK, and is expected to effectively prevent recurrence of cancer, thus being useful as a composition for preventing or treating cancer.Cette invention concerne un dérivé de pyrimidine-2,4-diamine ou des sels pharmaceutiquement acceptables de celui-ci, et une composition pharmaceutique le contenant à titre de principe actif pour prévenir ou traiter le cancer. Le composé selon linvention est extrêmement efficace pour supprimer lactivité kinase du lymphome anaplasique (ALK), et peut par conséquent, améliorer lefficacité du traitement des cellules cancéreuses contenant des protéines de fusion à base de ladite kinase du lymphome anaplasique (ALK), telles EML4-ALK et NPM-ALK, et devrait prévenir efficacement la récurrence du cancer, étant ainsi utiles à titre de composition pour prévenir ou traiter le cancer.본 발명은 피리미딘-2,4-디아민 유도체 또는 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 발명에 의한 화합물은 역형성 림프종 키나아제(ALK) 활성을 억제하는 효과가 우수하므로 이에 따른 EML4-ALK, NPM-ALK 등의 역형성 림프종 키나아제(ALK) 융합 단백질을 가진 암세포에 대한 치료효과가 향상될 수 있으며, 암의 재발을 막는데 효과적일 것으로 예상되므로 암의 예방 또는 치료용 약학적 조성물로 유용하게 사용될 수 있다.
