The present disclosure is related to a method and apparatus for determining a physiologic perturbation of a patient including acquiring a video sequence including a plurality of video frames of an eye of a patient selecting at least one parameter of a plurality of parameters including a baseline pupil size a maximum change in size of a pupil an average velocity of constriction of the pupil a maximum velocity of constriction of the pupil latency of constriction of the pupil and a velocity of re dilation of the pupil determining using processing circuitry and based on the plurality of video frames the selected at least one parameter of the plurality of parameters and determining the physiologic perturbation of the patient based on the determined at least one parameter where the least one parameter of the plurality of parameters is selected based on which physiologic perturbation of the patient is to be determined.
