PURPOSE: A composite including effective elements and a pancastatin mixture is provided to treat and prevent diseases generated by the over-expression of GRP78. CONSTITUTION: A pancastatin mixture and solvent are indicated as a chemical formula 1. R is a saturation or a non-saturation acyl group including carbon. The pancastatin mixture is manufactured by using an alcohol extraction step of ponciri fructus, a distribution extraction step, and a chromatogram step. The ponciri fructus is extracted as aliphatic alcohol including carbon. The alcohol extract is extracted by using organic solvent. The solvent distribute extract is extracted by using the chromatogram step.본 발명은 GRP78의 발현을 저해하는 신규한 판카스타틴 화합물을 제공한다. 또한 본 발명은 판카스타틴 화합물을 유효성분으로 포함하는 암의 예방 또는 치료용 조성물을 제공한다.
