The Research Foundation for The State University of New York
发明人:
Juliane NGUYEN,Scott FERGUSON
申请号：
US16612734
公开号：
US20200080092A1
申请日:
2018.05.11
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Presented are RNA nucleotide sequences referred to as EXO-Codes, and longer RNA polynucleotides that contain the EXO-Codes. EXO-Codes provide RNA with the ability to a) be selectively sorted to extracellular vesicles such as exosomes, and b) deliver a variety of cargo types to program or reprogram the extracellular vesicles, and cells that receive the exosomes. Also presented are methods of making the EXO-Codes, modifying cells using the EXO-Codes, expression vectors encoding the EXO-Codes, and exosomes and other secreted vessices that include RNA polynucleotides that contain the EXO-Codes.
