PROVISION OF NEW CARDIOMYOCYTE PROGENITOR CELLS AND CARDIOMYOCYTES DERIVED THEREFROM

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专利权人:

LEAD PHARMA CEL MODELS IP B.V.

发明人:

GOUMANS, MARIE, JOSE,DOEVENDANS, PIETER

申请号：

NZ57872808

公开号：

NZ578728A

申请日:

2008.01.09

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

Disclosed are human cardiomyocyte progenitor cells (CMPCs) from human heart tissue that are characterised by the Sca-1 or Sca-1 eptiope and CD31 on the cell surface. Further disclosed are methods for ex vivo isolation of CMPCs and differentiation of CMPCs into mature cardiomyocytes using a demethylating agent (5-azacytidine or 5-aza-2-deoxycytidine) and TGF-beta. Further disclosed are pharmaceutical compositions comprising cardiomyocytes for use in cardiomyocyte replacement therapy and for the treatment of myocardial infarction or for ameliorating the effects of myocardial infarction.

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中国工程科技知识中心

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http://www.ckcest.cn/home/