A medical tubing holder system includes a connector, a holding assembly and a retainer block. The holding assembly has an arm, and optional flanges to capture part of medical tubing, such as an endotracheal tube. The retainer block is distal from the holding assembly. The retainer block defines an aperture that receives a tube therein. The aperture is smaller than a tube flange placed between the block and the holding assembly, so as to capture the tube flange. An attachment element joins the holding assembly to the retainer block, and has length that is adjustable to selectively vary a distance between the block and the holding assembly. The attachment element effectively secures the retainer block, holding the tube flange, to the holding assembly and connector, which is secured to the patients head, to prevent self or accidental extubation. A related method is provided.