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COMPOSITIONS MEDICINALES AMELIOREES COMPRENANT DE LA BUBRENORPHINE ET DU NALMEFENE
专利权人:
RECKITT BENCKISER HEALTHCARE (UK) LIMITED
发明人:
CHAPLEO, CHRISTOPHER BOURNE,HYDE, NEIL
申请号:
CA2678568
公开号:
CA2678568C
申请日:
2008.02.15
申请国别(地区):
CA
年份:
2015
代理人:
摘要:
An analgesic composition, in parenteral unit dosage form or in a unit dosage form suitable for delivery via the dermis or mucosa, comprises buprenorphine and an amount nalmefene such that the ratio by weight of buprenorphine to nalmefene delivered to or reaching the plasma of a patient is in the range 22.6:1 to 40:1. The analgesic action of the buprenorphine is potentiated by the low dose of nalmefene. Also provided are a method of treatment of pain and the use of nalmefene and buprenorphine for the manufacture of a medicament.
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