Including a pharmaceutical combination :(a) the specific phosphatidylinositol--3-kinase inhibitor of one α-isoforms (S)-adjoin and cough up alkane -1,2- dicarboxylic acids 2- amide 1-({ 4- methyl -5- [2-(2,2,2- trifluoros -1,1- dimethyl-ethyIs)-pyridin-4-yl]-thiazol-2-yl }-amide) or its any pharmaceutically acceptable salt, (b) mTOR inhibitor and (c) Exemestane or its any pharmaceutically acceptable salt, especially it is used for the treatment or prevention of a proliferative disease This combined use in the preparation process of a medicament of the treatment or prevention for a proliferative disease The combined pharmaceutical compositions and method of the curative drug, the proliferative disease handled in a main body includes facilitating this combination effective dose of subject one.
