Disclosed is a traditional Chinese medicine combination for regulating immune function and its preparation , wherein the combination is prepared from Chinese medicine including Radix Panacis Quinquefolii, Ganoderma, fermentative cordyceps sinensis powder, Flos Rosae Rugosae , Rhizoma Anemarrhenae , Bulbus Lilii and the like as raw materials by disintegrating, water grilling alcohol extraction etc. to obtain various clinically acceptable formulations. The combination has the effects of preventing and curing hypersensitivity disease ,hepatitis B and AIDS , increasing leucocyte, preventing radiation injury , decreasing the by -effect of chemotherapy and radiotherapy , improving male sexual function, strengthening immunity , and alleviating physical fatigue.