PROCÉDÉ DE PRÉPARATION D'UNE COMPOSITION AYANT UNE FAIBLE TENEUR EN OXYGÈNE DISSOUS, COMPRENANT DE L'ACÉTAMINOPHÈNE ET ÉVENTUELLEMENT UN OU PLUSIEURS AINS, ET COMPOSITION OBTENUE PAR CE PROCÉDÉ
The present invention provides a method for preparing an intravenously administrable aqueous composition comprising acetaminophen, and optionally one or more non-steroidal anti-inflammatory drugs (NSAIDs), whereby the dissolved oxygen of the composition in a closed container is maximally 1.0 ppm, said method comprises rinsingat least once a compounding vessel with water of a temperature of at least 80°C, thereby heating the vessel and creating an oxygen low environment in said vessel； and in said rinsed vessel dissolving acetaminophen in water for injection, said water for injection is at a temperature of at least 80°C, whereby optionally one or more NSAIDS are added prior or after dissolving of acetaminophen.
