ANTICORPS DU RECEPTEUR DU FACTEUR DE CROISSANCE ANTI-EPIDERMIQUE HUMAIN

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专利权人:

IMCLONE SYSTEMS INCORPORATED

发明人:

LIU, MEILIN,ZHU, ZHENPING

申请号：

CA2560305

公开号：

CA2560305C

申请日:

2005.03.21

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

The present invention provides a fully human antibody that binds human EGFRwith affinity comparable to or higher than IMC-C225, and that neutralizesactivation of EGFR. Antibodies include whole immunoglobulins, monovalent Fabsand single chain antibodies, multivalent single chains antibodies, diabodies,triabodies, and single domain antibodies. The invention further providesnucleic acids and host cells and animals that encode and express theseantibodies. The invention further provides a method for neutralizingactivation of EGFR, treating in a mammal with neoplastic growth and non-cancerous hyperproliferative diseases using the antibodies alone or incombination with other agents.

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中国工程科技知识中心

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http://www.ckcest.cn/home/