БОЙЛАН Джон Фредерик (US),ЛАИСТРО Леопольдо Ладорес III (US),ПАКМАН Катрин Э. (US)
申请号：
RU2010133489/15
公开号：
RU2010133489A
申请日:
2009.01.05
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. Application of the compound (1)! ! or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the treatment of cancer, especially dense tumors. ! 2. The use according to claim 1, wherein the treatment comprises administering a compound (1) in a therapeutically effective amount of from about 400 to about 9000 ng × h / ml. ! 3. The use according to claim 2, in which the therapeutically effective amount of compound (1) is from about 1100 to about 4100 ng × h / ml. ! 4. The use according to claim 3, in which a therapeutically effective amount of compound (1) is from about 1380 to about 2330 ng × h / ml. ! 5. The use according to claim 2, in which a therapeutically effective amount of compound (1) is from about 400 to about 9000 ng × h / ml when administered over a period of time up to about 21 days. ! 6. The use according to claim 3, in which a therapeutically effective amount of compound (1) is from about 1100 to about 4100 ng × h / ml when administered over a period of time up to about 21 days. ! 7. The use according to claim 4, in which the therapeutically effective amount of compound (1) is from about 1380 to about 2330 ng × h / ml when administered over a period of time up to about 21 days. ! 8. The use according to claim 1, in which the compound (1) is administered once a day on days 1, 2, 3, 8 and 10 of a 21-day cycle. ! 9. The use of claim 8, in which the compound (1) is administered once a day on days 1, 2, 3, 8, 9 and 10 of a 21-day cycle in an amount of from about 400 to about 9000 ng × h / ml. ! 10. The use according to claim 1, in which the compound (1) is administered once a day on days 1-7 of a 21-day cycle. ! 11. The use of claim1. Применение соединения (1) ! ! или его фармацевтически приемлемой соли для приготовления лекарственного средства, предназначенного для лечения рака, прежде всего плотных опухолей. ! 2. Применение по п.1, в котором лечение предусматривает введение соединения (1) в терапевтически эффективном ко
