The present invention relates to pharmaceutically accepted complex formulae comprising complexes of Cyclosporine A or derivatives thereof and complexation agents and pharmaceutically accepted excipients, process for the preparation thereof and pharmaceutical compositions containing them. The complex formulae of the present invention have improved physicochemical properties and decreased variability and food effect and are useful in the treatment of transplant (kidney, liver, and heart) rejection, rheumatoid arthritis and severe psoriasis.
