HUTCHINSON DOUGLAS K.,BARNES DAVID M.,WAGNER ROLF,TUFANO MICHAEL D.,PRATT JOHN K.,MOTTER CHRISTOPHER E.,LONGENECKER KENTON L.,HUANG PEGGY P.,BETEBENNER DAVID A.,GAO YI,FRANCZYK II THADDEUS S.,ROCKWAY
申请号：
NZ61827708
公开号：
NZ618277A
申请日:
2008.09.17
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed are Uracil or Thymine derivatives of formula (I) useful to treat hepatitis C (HCV) infections. In the structure of the disclosed compounds is the uracil or thymine derivative linked via a phenylene into either fused 2-ring cyclic system (R6) or alternatively via additional two-atom linker (L) to a 5-6 membered monocycle (R6). Application further discloses polymorphs and pseudopolymorphs of two specific compounds: N-(6(3-t-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1-(2H)-yl)2-methoxy-phenyl)naphthalen-2-yl)methanesulfonamide and (E)-N-(4(3-t- butyl-5-(2,4-dioxo-3)4-dihydropyrimidin-1-(2H)-yl)2-methoxy-styryl-phenyl)methanesulfonamide. Also disclosed are crystalline forms of the compounds and processes for preparing the compounds and the crystal forms.
