The invention relates to deoxyribonuclease for use in the treatment of a suspected or existing C. difficile infection a pharmaceutical or veterinary composition or formulation comprising at least deoxyribonuclease for use in the treatment of a suspected or existing C. difficile infection a combination therapeutic comprising at least deoxyribonuclease for use in the treatment of a suspected or existing C. difficile infection a method of treating a mammal suspected of being infected with, or infected with, C. difficile comprising the use of at least deoxyribonuclease a method of cleaning or sterilising a material or product comprising the use of at least deoxyribonuclease and a cleaning or sterilising product impregnated with or containing at least deoxyribonuclease.