Method for screening harmful responses of skin by pollen house dust mite or yellow sand dust and the composition for skin external application controlling the responses
The present invention provides a method for screening a substance involved in inducing skin irritation or a substance inhibiting it, a method for screening a substance that alleviates skin irritation, and a method for screening a substance that alleviates skin irritation by screening a gene whose expression amount is changed by environmental harmful factors such as pollen, house dust mite, The present invention relates to a composition for external application for skin, which contains at least one kind of extract of Ganoderma lucidum and Ganoderma lucidum as an active ingredient to alleviate harmful effects of skin caused by pollen, house dust mites or dusts, and to detoxify and release toxins.(IL-6), IL-8 (interleukin 8), GST (interleukin 6), house dust mite, Pollen, Yellow Sand Dust, keratinocyte, Keratinocyte, Glutathione-S-Transferase), NQO1 (NADPH Quinone Oxidoreductase 1), hBD3 (human β-defensin 3)본 발명은 꽃가루, 집먼지 진드기 또는 황사와 같은 환경유해인자에 의하여 발현량이 변화하는 유전자를 스크리닝함으로써 피부자극을 유도하는데 관여하는 물질 또는 이를 억제하는 물질, 피부 자극을 완화시키는 물질을 스크리닝하는 방법, 및 고련피와 관동화 추출물 중 1종 이상을 유효성분으로 함유하여 꽃가루, 집먼지 진드기 또는 황사에 의한 피부 유해영향을 완화하며 독소를 해독하고 배출하는 피부 외용제 조성물에 관한 것이다.
