PROBLEM TO BE SOLVED: To provide a pharmaceutical composition capable of blocking an inflammatory response even when administered after occurrence of the inflammatory response to treat the inflammation.SOLUTION: A pharmaceutical composition for treatment of inflammation includes: an antibody or an antigen-binding fragment thereof recognizing the Toll-like receptor 4 (TLR4) and suppressing inflammation after occurrence of an inflammatory response. In use of the pharmaceutical composition for treatment of inflammation, the antibody or the antigen-binding fragment thereof is administered to a subject causing the inflammatory response.COPYRIGHT: (C)2014,JPO&INPIT【課題】炎症反応惹起の後に投与しても炎症反応を遮断して炎症を治療することができる医薬組成物を提供する。【解決手段】Toll様受容体4 (TLR4)を認識し、かつ炎症反応惹起後の炎症を抑制する抗体又はその抗原結合性断片が、炎症反応を惹起した対象に投与されるように用いられることを特徴とする、前記抗体又はその抗原結合性断片を含有する炎症治療用医薬組成物。【選択図】なし
