PAUL MICHAEL SCOLA,ERIC P. GILLIS,ERIC MULL,QIAN ZHAO,LI SUN,KENNETH M. QIANG - BOY
申请号：
ARP160100725
公开号：
AR103969A1
申请日:
2016.03.17
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
Claim 1: A compound characterized by the formula (1) or a pharmaceutically acceptable salt thereof, wherein: A is selected from the compounds of the group of formulas (2) wherein: the wavy line * indicates the point of attachment to the carbonyl group and the wavy line indicates the point of attachment to the nitrogen atom； n is 0 or 1； m is 1 or 2； w is 0, 1 or 2； R¹⁴ and R¹⁵ are independently selected from hydrogen and methyl； R¹⁶ᵃ is selected from hydrogen and C₁₋₆ alkyl； R¹⁶ is selected from - (C (R¹⁷ᵃ) ₂) -C (O) -NR⁵⁰R⁵¹；wherein: each R¹⁷ᵃ is independently selected from hydrogen and C₁₋₆ alkyl； one of R⁵⁰ and R⁵¹ is selected from hydrogen and C₁₋₆ alkyl, and the other is selected from - (CH₂) ₙX, C₁₋₆ alkyl, C₃₋₇ cycloalkyl, heterocyclyl and phenyl, wherein the cycloalkyl is optionally substituted with 1 , 2 or 3 groups independently selected from C₁₋₃ alkoxy, C₁₋₃ alkyl, amino, cyano and hydroxy, or； R⁵⁰ and R⁵¹,together with the nitrogen atom to which they are attached, they form a saturated, unsaturated ring of four, five, six or seven members that optionally contain one or two additional heteroatoms independently selected from nitrogen, oxygen and sulfur； wherein the ring is optionally substituted with one, two or three groups selected from C₁₋₆ alkoxy, C₁₋₃ alkyl, cyano, halo, halo-C₁₋₃ alkyl, hydroxy, hydroxy (C₁₋₃ alkyl),-8311； 8304； 8311；oxo and phenyl； wherein phenyl is optionally substituted with one, two or three groups independently selected from C₁₋₃ alkoxy, cyano and halo； n is 1-5； X is selected from a remainder of formula (3),Formula (4),C₂₋₆ alkoxymethyl, C₁₋₆ alkoxycarbonylmethyl, C₁₋₆ alkylsulfanylmethyl, C₁₋₆ alkylsulfonylmethyl, azidomethyl, tert-butoxymethyl, C₃₋₇ cycloalkyl, haloalkoxymethyl, halomethyl, heterocyclyl, hydroxymethyl, isopropoxymethyl, (NR⁷⁰R⁷¹) methyl, phenyl, phenyl, methyl Phenylsulfanylmethyl, one of R⁷⁰ and R⁷¹ is selected from hydrogen, C₁₋₆ alkyl and hydroxy-C₂₋₆ alkyl, and the other is selected from C₁₋₆ alkoxycarbo
