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INHIBITORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND USES THEREOF
专利权人:
Dana-Farber Cancer Institute; Inc.
发明人:
Nathanael S. Gray,Tinghu Zhang,John Hatcher,Sara Jean Buhrlage
申请号:
US16462200
公开号:
US20190276426A1
申请日:
2017.11.22
申请国别(地区):
US
年份:
2019
代理人:
摘要:
The present invention provides novel compounds of Formula (I′;), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating and/or preventing proliferative diseases (e.g., cancers (e.g., leukemia, lymphoma)), inflammatory diseases, autoinflammatory diseases, and autoimmune diseases in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as an interleukin-1 receptor-associated kinase (IRAK) (e.g., IRAKI and/or IRAK4) in the subject.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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