Methods and systems for applying CIPC and/or other sprout-inhibiting substances to post-harvest potatoes and/or other vegetables are disclosed herein. In one embodiment, a method of applying sprout inhibitor includes directing a first portion of an aerosol of the sprout inhibitor toward a top portion of a pile of potatoes, and then directing a second portion of the aerosol toward a bottom portion of the pile. In one aspect of this embodiment, directing the aerosol toward a top portion of the pile can include operating a facility fan at a flow rate of 6 SCFM or more in a first direction, and directing the aerosol toward a bottom portion of the pile can include operating the fan at a flow rate of 6 SCFM or more in a second direction, opposite to the first direction. In another aspect of this embodiment, the sprout inhibitor aerosol can include a mixture of CIPC and solvent (e.g., clove oil) that remains liquid at temperatures less than 105° F.