Seung K. Kim,William Goodyer,Gerald R. Crabtree,Pei Wang
申请号：
US13940135
公开号：
US20140030234A1
申请日:
2013.07.11
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Methods and compositions are provided for modulating pancreatic islet β-cell development. Aspects of the methods include promoting β-cell development by providing agents that promote calcineurin/N FAT signaling, and inhibiting β-cell development by providing agents that inhibit calcineurin/NFAT signaling. These methods find a number of uses, including, for example, in the treatment of diabetes and human islet diseases. In addition, reagents, devices and kits thereof that find use in practicing the subject methods are provided.
