Provided are electrokinetically-altered fluids (gas-enriched electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for use in treating inflammatory neurodegenerative condition or disease or at least one symptom thereof. The electrokinetically-altered fluids or therapeutic compositions and methods include electrokinetically-altered ioinic aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for regulating or modulating intracellular signal transduction associated with said inflammatory responses by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids (e.g., electrokinetically-altered gas-enriched fluids and solutions) and therapeutic compositions.La présente invention concerne des fluides à modification électrocinétique (fluides électrocinétiques enrichis en gaz) comprenant une solution aqueuse ionique de nanostructures contenant de l’oxygène à charge stabilisée en une quantité suffisante pour produire la modulation d’au moins l’un parmi le potentiel de membrane cellulaire et la conductivité de membrane cellulaire, et des compositions et procédés thérapeutiques pour utilisation dans le traitement d’une pathologie ou maladie neurodégénérative inflammatoire ou au moins un symptôme de celle-ci. Les fluides à modification électrocinétique ou les compositions et procédés thérapeutiques comprennent des fluides aqueux ioniques à modification électrocinétique facul
