The invention relates to the discovery that collagenase injections areeffective in lyse the collagenous adhesions in the shoulder and treat thedisorder, adhesive capsulitis. As such, the invention relates to methods oftreating or preventing adhesive capsulitis, or frozen shoulder, in a patientin need of such treatment comprising injecting or otherwise delivering aneffective amount of collagenase to the collagenous adhesions in the shoulder.The invention also relates to the use of collagenase in the manufacture of amedicament to treat adhesive capsulitis.