Provided herein are combinations comprising HDACi and PD-L1 inhibitors useful for the treatment of cancer, including cancers resistant to PD-1 inhibitors. [Selected figure] Figure 1本明細書では、PD-1阻害剤に耐性のがんを含む、がんの治療に有用なHDACiおよびPD-L1阻害剤を含む組み合わせが提供される。【選択図】図1