PROBLEM TO BE SOLVED: To provide a pharmaceutical composition comprising as an effective ingredient a nitrogen-containing heterobicyclic compound affinitive for a mineralocorticoid receptor (MR).SOLUTION: The pharmaceutical composition comprises as an effective ingredient a compound represented by general formula [I] [wherein the ring A is a benzene ring or the like optionally bearing a substituent group other than R1 R1 is a group represented by the formula: RaSO2NH-, or the like Ra is an alkyl group or the like R2 and R3 are the same or different and are each a hydrogen atom, a phenyl group, an optionally substituted alkyl group, or the like X is an oxygen atom or the like Y is a group represented by the formula: -C(=O)-, or the like Ar is an optionally substituted aryl group or an optionally substituted heteroaryl group Q is a single bond, an alkylene group or the like] or a pharmaceutically acceptable salt thereof.COPYRIGHT: (C)2009,JPO&INPIT【課題】鉱質コルチコイド受容体(MR)に親和性を有する含窒素複素二環式化合物を有効成分としてなる医薬組成物を提供する。【解決手段】一般式[I]:〔式中、環Aは、R1以外にも置換基を有していてよいベンゼン環等、R1は式:RaSO2NH-で示される基等、Raはアルキル基等、R2及びR3は同一又は異なって水素原子、フェニル基、置換されていてもよいアルキル基等、Xは酸素原子等、Yは式:-C(=O)-で示される基等、Arは置換されていてもよいアリール基又は置換されていてもよいヘテロアリール基、Qは単結合手、アルキレン基等を表す。]で示される化合物又はその薬理的に許容し得る塩を有効成分としてなる医薬組成物。【選択図】なし
