COYLE, ANTHONY,YAO, YIHONG,JALLAL, BAHIJA,CARLESSO, GIANLUCA,BOWEN, MICHAEL
申请号：
CA2685465
公开号：
CA2685465C
申请日:
2008.05.07
申请国别(地区):
CA
年份:
2020
代理人:
摘要：
The present invention provides anti-human ICOS antibodies with increasedeffector function. The invention furtherrelates to pharmaceutical compositions, immunotherapeutic compositions, andmethods using therapeutic antibodies that bind to thehuman ICOS antigen and that may mediate ADCC, CDC, and/or antibody-dependentphagocytosis (opsonisation) for the treatmentand prevention of T cell-mediated diseases and disorders, such as, but notlimited to, chronic infection, autoimmune disease ordisorder, inflammatory disease or disorder, graft-versus-host disease (GVHD),transplant rejection, and T cell proliferative disorder.
