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Anti-RSV immunogens and methods of immunization
专利权人:
The United States of America being represented by the Secretary of the Department of
发明人:
Larry J. Anderson,Lia M. Haynes,Ralph A. Tripp
申请号:
US13763822
公开号:
US08771706B2
申请日:
2013.02.11
申请国别(地区):
US
年份:
2014
代理人:
摘要:
Immunogenic polypeptides corresponding to one or more RSV G glycoproteins, or analogs thereof, are provided as components of vaccines. The inventive compositions are useful as both a prophylactic and therapeutic for the prevention and treatment of RSV infections and associated pulmonary or other diseases. The inventive immunogens include regions of the RSV G protein, specifically, amino acid residues 164-176 of RSV G A2 protein or analogs thereof. This inventive immunogen is operable alone or in combination with other polypeptides such as the RSV G protein amino acid residues 155-206, or other vaccines such as live RSV vaccines, or inactivated RSV vaccines or immunogenic analogs thereof.
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