Disclosed is the use of a topical pharmaceutical preparation comprising a supernatant of a physiological solution comprising peripheral blood mononuclear cells (PBMCs) or a subset thereof in a physiological solution free of PBMC-proliferating and PBMC-activating substances in the manufacture of a medicament for treating an inflammatory skin condition. Further disclosed is a method for preparing a topical pharmaceutical preparation comprising the steps of a) providing peripheral blood mononuclear cells (PBMCs) or a subset thereof, b) culturing the cells of step a) in a physiological solution free of PBMC-proliferating and PBMC-activating substances for at least 1 h, c) isolating the supernatant of step b), and d) preparing the pharmaceutical preparation using the supernatant of step c) .
