A modular analyte measurement system having a removable strip port module. In one embodiment, the analyte measurement system includes: an analyte meter； a removable strip port module； and a connector linking the removable strip port module to the analyte meter. The analyte meter includes: a meter housing； a receptacle formed in the meter housing； a processing circuit disposed within the housing； and an input interface within the receptacle and electrically coupled to the processing circuit. The removable strip port module includes: a module housing sized to at least partially fit within the receptacle of the analyte meter； an analyte test strip port disposed within the module housing to receive an analyte test strip via an aperture formed in the module housing； and an output interface coupled to the analyte test strip port. The connector links the output interface with the input interface.
