KONRADI, ANDREI, W.,PLEISS, MICHAEL, A.,SEMKO, CHRISTOPHER, M.,YEDNOCK, THEODORE,SMITH, JENIFER, L.
申请号：
HK08102319.2
公开号：
HK1111674B
申请日:
2008.02.29
申请国别(地区):
HK
年份:
2012
代理人:
摘要：
Disclosed are conjugates which bind VLA-4. Certain of these conjugates also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such conjugates are useful in the treatment of inflammatory diseases in a mammalian patient, e.g ., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The conjugates can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
