Lars LANNFELT,Joakim BERGSTRÖM,Martin INGELSSON,Pär GELLERFORS
申请号：
US16543854
公开号：
US20200215209A1
申请日:
2019.08.19
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Methods for detecting α-synuclein oligomers in vivo comprise administering an antibody to an individual suspected of carrying soluble α-synuclein, wherein the antibody is produced from a stabilized soluble α-synuclein oligomer and is capable of binding the stabilized soluble α-synuclein oligomer, wherein the stabilized soluble α-synuclein oligomer has a lower formation rate to a non-soluble aggregated form than a non-stabilized soluble oligomer of the α-synuclein, and wherein the antibody is labelled with a detectable marker； and detecting the presence of any complex formed between the antibody and soluble α-synuclein by detection of the marker.
