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专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
Guido GALLEY,Roger NORCROSS,Philippe PFLIEGER,Hong SHEN,Yimin HU,Giuseppe CECERE
申请号:
MX2017001096
公开号:
MX2017001096A
申请日:
2015.07.29
申请国别(地区):
MX
年份:
2017
代理人:
摘要:
The present invention relates to compounds of formula (I), wherein L is a bond, -C(O)NH-, -NHC(O)-, -CH2NHC(O)-, CH2C(O)NH-, -CH2NH-, -NH- or -NHC(O)NH- R1 is hydrogen, lower alkyl, halogen, lower alkoxy-alkyl, lower alkoxy substituted by halogen, lower alkyl substituted by halogen or is phenyl or heteroaryl selected from the group consisting of pyridinyl, pyrimidinyl, pyrazinyl or pyrazolyl, and wherein phenyl and heteroaryl are optionally substituted by one, two or three substituents selected from the group consisting of halogen, lower alkyl, lower alkoxy, lower alkyl substituted by halogen, lower alkoxy substituted by halogen, cycloalkyl or O-CH2-cycloalkyl or to a pharmaceutically suitable acid addition salt thereof, to all racemic mixtures, all their corresponding enantiomers and/or optical isomers, which may be used for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders, schizophrenia, neurological diseases, Parkinsons disease, neurodegenerative disorders, Alzheimers disease, epilepsy, migraine, hypertension, substance abuse, metabolic disorders, eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.La presente invención se refiere a compuestos de fórmula (ver Fórmula) en la que L es un enlace, -C(O)NH-, -NHC(O)-, -CH2NHC(O)-, CH2C(O)NH-, -CH2NH-, -NH- o -NHC (O) NH- R1 es hidrógeno, alquilo inferior, halógeno, alcoxi inferior-alquilo, alcoxi inferior sustituido con halógeno, alquilo inferior sustituido con halógeno o es fenilo o heteroarilo seleccionado entre el grupo que consiste en piridinilo, pirimidinilo, pirazinilo o pirazolilo, y en el que el fenilo y el heteroarilo están opcionalmente sustituidos con uno, dos o tres sustituyentes seleccionados entr
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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