A method of manufacturing a microneedle and a structure with an array of microneedles manufactured by using the method, in which a size, height, and shape of the microneedle formed on a base may be adjusted. The multiple microneedles may be uniform in size, height, and shape even though the multiple microneedles are simultaneously formed on the base. The method is economical because precise control is not required and an area of the structure with the array of microneedles may be increased only with a simple facility. The structure with an array of multiple fine microneedles formed on the base (or substrate), includes the microneedle having an upper end having a fine diameter that does not cause pain or trauma to the skin, and includes sufficient hardness required to penetrate a skin layer, and sufficient effective length and a stable shape delivering active ingredients to capillaries.
