I will provide an antigen-binding portion of the antibody and their human antibody that specifically binds to the expansion I Katakusari glycosphingolipid. The invention also includes nucleic acid sequences and their corresponding amino acid sequences of the variable light chain and variable heavy chain of the antibody. Comprises for obtaining a binding molecule comprising a CDR derived region complementarity determining regions or one or more (CDR), the CDR region sequences of an antibody of interest, another embodiment of the present invention, they are the CDR region sequences I hold an extended Type I glycosphingolipid binding capacity of the parent molecule were obtained.拡張I型鎖スフィンゴ糖脂質に特異的に結合するヒト抗体およびそれらの抗体の抗原結合部分を提供する。本発明はまた、該抗体の可変重鎖および可変軽鎖のアミノ酸配列およびそれらの対応する核酸配列を含む。本発明の別の実施形態は、1つまたは複数の相補性決定領域(CDR)またはCDR由来領域を含む結合分子を得るための、目的の抗体のCDR領域配列を含み、該CDR領域配列はそれらが得られた親分子の拡張I型スフィンゴ糖脂質結合能力を保持する。