The present invention provides acylsulfonamides including bumetanide derivatives and compositions comprising such analogs. The present invention also provides pharmaceutical compositions containing these compounds and methods for their use. All of these analogs are particularly useful for the treatment and/or prophylaxis of conditions that involve the Na+K+Cl- co-transporter or GABAA receptor including but not limited to addictive disorders, Alzheimers Disease, anxiety disorders, ascites, attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (autism), bipolar disorder, cancer, the improvement of cognitive function, cognitive impairment, cognitive dysfunction, depression, endothelial corneal dystrophy, edema, epilepsy, glaucoma, Huntingtons Disease, inflammatory pain, insomnia, ischemia, migraine, migraine with aura, migraine without aura, neuropathic pain, nociceptive neuralgia, nociceptive pain, ocular diseases, pain, Parkinsons disease, periodic limb movement disorder (PLMD), personality disorders, postherpetic neuralgia, psychosis, restless legs syndrome (RLS), schizophrenia, seizure disorders, spasticity, tinnitus, and withdrawal syndromes.La présente invention concerne des acylsulfonamides comprenant des dérivés de bumétanide, ainsi que des compositions contenant lesdits analogues. La présente invention concerne également des compositions pharmaceutiques contenant lesdits composés, ainsi que leurs méthodes dutilisation. Tous ces analogues peuvent, en particulier, être utilisés en vue du traitement et/ou de la prophylaxie daffections impliquant le cotransporteur Na+K+Cl- ou le récepteur GABAA, parmi lesquelles on peut notamment citer, mais la liste nest pas limitative, les troubles addictifs, la maladie dAlzheimer, les troubles de lanxiété, lascite, le trouble déficitaire de lattention avec hyperactivité, les troubles du spectre autistique (autisme), le trouble bipolaire, le cancer, lamélioration de la fonction cognitive, la déficience cogni
