Martin Kean Chong Ng,Anna Waterhouse,Anthony Steven Weiss,Steven Garry Wise
申请号：
US12652926
公开号：
US08808365B2
申请日:
2010.01.06
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Biocompatible materials for use in vascular applications or for implantation have been engineered, combining human recombinant tropoelastin with other synthetic or natural biomaterials to form protoelastin. The materials can be in the form of elastin films on metal or polymer substrates, laminates of alternating polymer and elastin, blends of polymer and elastin, or elastin crosslinked with or tethered to polymer or metal. These are mechanically stable, elastic, strong and biocompatible (i.e., not thrombogenic and promoting adhesion of cells, especially human endothelial cells), not eliciting a foreign body response. Plasma polymerization of substrate is shown to enhance biocompatibility, especially when used to bind elastin or other protein to the substrate.
