Randolph J. Noelle,Li-Fan Lu,Sergio Quezada,David Gondek
申请号：
US11912397
公开号：
US08236304B2
申请日:
2006.04.24
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates αCD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon αCD3/αGITR stimulation. This protein has been designated Treg-sTNF. Proteins, antibodies, activated T cells and methods for using the same are disclosed.
