A compound represented by structural formula (V): or one of its pharmaceutically acceptable salts, solvates or clathrates, wherein: each Z is independently selected from the group consisting of a lower alkyl, a lower haloalkyl, a halogen, a lower alkoxy, a lower alkylsulfanyl, cyano, nitro or lower haloalkoxy； R12 is an aryl or a heteroaryl, wherein the aryl and the heteroaryl are optionally substituted with one or more substituents selected from the group consisting of an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, a cycloalkenyl optionally substituted, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl or an optionally substituted heteroaralkyl, a halogen, cyano, nitro, -OR17, -SR17, -S (O) pR17, -S (O) for 17, -OS (O) p17, -OS (O) for 17, -NR17S (O) p17, -S (O) pNR15R16, -NR15R16, -C (X3) R17, -C (X3) OR17, -C (X3) SR17, -C (X3) NR15R16, -NR17C (X3) R18, -NR17C (X3) OR18, - NR17C (X3) SR18, -NR17C (X3) NR15R16, -OC (X3) R17, - OC (X3) OR17, -OC (X3) SR17, -SC (X3) OR17, -SC (X3) SR17, - OC (X3) NR15R16, -SC (X3) NR15R16, -P (X4) (X5R17) 2 , -X5P (X4) (X5R17) 2, -P (X4) (R17) 2, -P (X4) (R17) (X5R17)； R13 is an aryl or a heteroaryl, wherein the aryl and the heteroaryl are optionally substituted with one or more substituents selected from the group consisting of an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, a cycloalkenyl optionally substituted, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl or an optionally substituted heteroaralkyl, a halogen, cyano, nitro, a haloalkyl, -OR17, -SR17, -S (O) pR17, -S (O ) pOR17, -OS (O) pR17, -OS (O) pOR17, -S (O) pNR15R16, -NR15R16, -C (X3) R17, - C (X3) OR17, -C (X3) SR17, -C (X3) NR15R16, -NR17C
