Inhibitory RNAs to RNA binding proteins hnRNPA1, hnRNPA2 and PTB and uses thereof

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专利权人:

James L. Manley

发明人:

James L. Manley,Mo Chen,Charles David,Jian Zhang

申请号：

US13582921

公开号：

US09206426B2

申请日:

2011.03.07

申请国别(地区):

US

年份:

2015

代理人:

摘要：

Provided herein are methods to reduce or slow down cell growth, for example in a cancer cell comprising contacting a cell with an effective amount of a combination of inhibitory RNA molecules targeting hnRNPA1, hnRNPA2 and PTB. Provided are methods to identify agents which reduce the levels of hnRNPA1, hnRNPA2 or PTB. Provided are methods to identify agents which increase ratio of PKM1/PKM2 proteins, or reduce PKM2 levels, or increase PKM1 levels.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/