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PROTEINE NAGLU HUMAINE RECOMBINANTE ET SES UTILISATIONS
专利权人:
SYNAGEVA BIOPHARMA CORP.
发明人:
QUINN, ANTHONY,LEAVITT, MARKLEY C.,ZHINAN, XIA,RUTKOWSKI, JOSEPH VICTOR
申请号:
CA2852027
公开号:
CA2852027A1
申请日:
2012.10.11
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
The present invention provides compositions comprising an isolated mixture of recombinant human NaGlu proteins in which a substantial amount of the NaGlu proteins in the mixture has increased levels of phosphorylated mannose that confer the proteins to be efficiently internalized into human cells. The present invention also provides methods of producing such mixture of NaGlu proteins, vectors used in transgenesis and expression, host cells harboring such vectors, and methods of isolating and purifying the mixture of NaGlu proteins. The invention further provides methods of treating NaGlu associated diseases.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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