Nucleic acid aptamers capable of binding to lymphocyte activation gene 3 (LAG-3) and uses thereof for modulating immune responses. Such aptamers may comprise a G-rich motif, for example, GX1GGGX2GGTX3A (SEQ ID No:1), in which each of X1and X2are independently G, C, or absent, and X3is T or C, or L-(G)n-L’, in which n is an integer of 5-9 inclusive, and L and L’ are nucleotide segments having complementary sequences. Also provided herein are multimeric nucleic acid aptamers containing a backbone moiety, which comprises a palindromic sequence.揭示了一種能結合淋巴細胞活化基因3(LAG-3)的核酸適體，及一種其用於調節免疫反應的用途。此類適體可包含富含G的模體，例如GX1GGGX2GGTX3A (SEQ ID No:1)，其中X1和X2各自獨立地為G、C或不存在，以及X3為T或C，或L-(G)n-L’，其中n為整數5至9，包括端值，且L和L’為具有互補序列的核苷酸區段。本文亦提供一種含有骨架部分的多聚核酸適體，其包含一迴文序列。
