您的位置: 首页 > 农业专利 > 详情页

Intravenous formulations of Coenzyme Q10 (CoQ10) and methods of use thereof
专利权人:
Berg LLC
发明人:
NARAIN, Niven Rajin,MCCOOK, John Patrick
申请号:
AU2020203490
公开号:
AU2020203490A1
申请日:
2020.05.27
申请国别(地区):
AU
年份:
2020
代理人:
摘要:
#$%^&*AU2020203490A120200618.pdf#####INTRAVENOUS FORMULATIONS OF COENZYME Q10 (COQ10) AND METHODS OF USETHEREOF Abstract Disclosed herein are formulations suitable for parenteral administration of certain hydrophobic active agents such as Coenzyme Q10. Methods of preparing the same and methods of treatment of oncological disorders using the same are also provided herein. The formulations comprise an aqueous solution; a hydrophobic active agent dispersed to form a colloidal nano-dispersion of particles; and at least one of a dispersion stabilizing agent and an opsonization reducer wherein the colloidal nano-dispersion of the active agent is dispersed into nano-dispersion particles having a mean size of less than 200-nm. Methods of preparing the parenteral formulations comprise dispersing the hydrophobic active agent by high pressure homogeniza-tion by (1) adding hydrophobic active agent to a 65°C bath of water and mixing to form a hydrophobic active agent/water mixture; (2) adding a dispersion stabilizing agent to the hydrophobic active agent/water mixture and mix at 65°C to form a hydrophobic active agent/water/stabilizer mixture; (3) adding an opsonization reducer to form a hydrophobic active agent/water/stabilizer/reducer mixture; (4) pre-heating a Microfluidizer to 65°C; and (5) processing by mixing the hydrophobic active agent/water/stabilizer/reducer mixture in the Microfluidizer at 65°C such that a hydrophobic active agent colloidal nanodispersion having a mean particle size less than 200-nm is formed. Provided herein are also methods of treating oncological disorders by administering formulations described herein to a subject such that treatment or prevention of the oncological disorder occurs.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充